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JCVI-syn3.0: Minimal Synthetic Cell with 473 Genes, 531,560 Base Pairs Created in 2016; 149 Genes Unknown

Target:UPSC GS-IIIMPSCTeachingPrelims HighMains High
17 May 2026
~2 min
Source: Indian Express
Key Data:473 genes531,560 base pairs149 unknown genes (2016)92 unknown genes (2022)2016Science
Bodies:JCVI
Practice MCQs from today's news ▸
What This Article Covers

1.Craig Venter and JCVI created JCVI-syn3.0, a minimal synthetic cell with 473 genes and 531,560 base pairs, published in Science in 2016.

2.149 of these essential genes have unknown functions, highlighting a major gap in our understanding of life's basic components.

3.This research is a critical case study for exams on synthetic biology, reductionism in science, and the limits of current bioengineering.

The Big Picture
Prelims · HighMains · High

This article highlights a landmark achievement in synthetic biology – the creation of the smallest self-replicating synthetic cell, JCVI-syn3.0 – and the profound scientific challenge it reveals. For exam aspirants, it underscores a key frontier in biotechnology: understanding the fundamental, yet unknown, building blocks of life, which is crucial for future applications in medicine, energy, and industry.

Exam Lens

Quick Exam Facts From News

Minimal Cell NameJCVI-syn3.0
Total Genes473
Total Base Pairs531,560
Unknown Function Genes (2016)149
Publication Year & Journal2016, Science
Researcher/TeamCraig Venter, JCVI
Updated Unknown Genes (2022)About 92 (in JCVI-syn3A)

1-Minute Revision

  • ›Minimal Cell Name: JCVI-syn3.0
  • ›Total Genes: 473
  • ›Target this Data: JCVI-syn3.0 has 473 genes and 531,560 base pairs.
  • ›Target this Data: 149 genes in JCVI-syn3.0 had unknown function in 2016.
  • ›Target this Nodal Body: J. Craig Venter Institute (JCVI).
  • ›Target this Publication: Research published in 'Science' journal in 2016.

Mastered this topic? Test your knowledge with a full MCQ quiz.

Practice exam-style questions, track your score, and strengthen your recall.

Q1Static LinkageEasy

Which research institute, led by Craig Venter, created the minimal synthetic cell JCVI-syn3.0?

Q2Statement-basedHard

Consider the following statements regarding the minimal synthetic cell JCVI-syn3.0:

1. It was created by Craig Venter and his team and published in the journal Science in 2016.

2. It contains 473 genes and 531,560 base pairs, all of which are understood and have assigned functions.

3. A derivative cell, JCVI-syn3A, had about 92 genes of unknown function in 2022, showing progress from the original 149.

Which of the statements given above is/are correct?

Q3Data-centricMedium

According to the article, what was the total number of genes in the minimal synthetic cell JCVI-syn3.0?

Q4Application/ImpactMedium

What is the primary scientific challenge highlighted by the creation of JCVI-syn3.0, according to the article?

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