CAR-T Therapy Shows Remission in Lupus, MS Trials; Targets B-Cell Aplasia for Autoimmune Diseases

Proposed Patient Data Collective (PDC) Model for Rare Diseases in India Inspired by Amul Cooperative

A new proposal suggests creating a Patient Data Collective (PDC) for rare diseases in India, modeled on the Amul dairy cooperative. This collective would pool patient data to accelerate drug discovery and clinical trials, addressing the challenge of small patient populations for rare diseases.

India Gets First Disease-Modifying Alzheimer's Drug Leqembi After CDSCO Nod

Eisai's Leqembi (lecanemab), India's first disease-modifying therapy for early Alzheimer's, has been launched after CDSCO approval. This marks a shift from symptomatic to disease-modifying treatment, but challenges of early diagnosis, biomarker infrastructure, and affordability remain significant.

Stem Cell Therapy for Autism Restricted to Clinical Trials; Health Ministry Advisory Follows SC Order

The Union Health Ministry has reiterated that stem cell therapy for Autism Spectrum Disorder (ASD) can only be offered as part of approved clinical trials, not as routine or commercial treatment. This follows a landmark Supreme Court judgment in January 2026 that examined the issue. The advisory reinforces existing regulations under the Clinical Establishments Act, 2010, and the National Guidelines for Stem Cell Research, 2017.

Candida auris Shows 90% Azole Resistance; Study Reveals Gene Duplication & Eagle Effect Challenging Antifungals

Fungal infections are rising due to global warming, with Candida auris emerging as a multidrug-resistant threat (30-40% mortality). New research from JNCASB and collaborators reveals that C. auris uses gene duplication (Erg11) and mutations (Fks1) to resist antifungals, and also exhibits the 'Eagle effect' where high drug doses paradoxically trigger compensatory chitin production, making the pathogen survive. This signals the end of the chemical arms race approach and calls for combination therapies and revised susceptibility testing limits.

MeitY Summons Meta Global Team Over Algorithmic Bias; Parliamentary Panel to Question

Government summons Meta's global team to clarify algorithmic bias and role in public order after MeitY rejects technical glitch explanation. Parliamentary panel will also question the company. This highlights growing regulatory scrutiny on social media algorithms and their societal impact.

WHO's IARC Classifies Hydrochlorothiazide, Voriconazole, Tacrolimus as Group 1 Carcinogens

Three widely used medicines for hypertension, fungal infections, and transplant rejection have been classified as Group 1 carcinogens by WHO's IARC. Patients are warned not to discontinue treatment without consulting doctors, as the classification identifies hazard, not real-world risk at prescribed doses.

NOTTO Reports 20,000+ Transplants in 2025, Launches Portal and Swap Guidelines

NOTTO released 2025 data showing over 20,000 transplants, persistent gender disparity in organ donation (68% female donors vs 78% male recipients), and launched a new digital portal to enhance transparency. New swap transplantation guidelines aim to expand matching beyond single hospitals, but legal recognition under THOTA is still pending.

IARC Classifies Three WHO Essential Medicines as Group 1 Carcinogens: Hydrochlorothiazide, Voriconazole, Tacrolimus

IARC, the WHO cancer research agency, has classified three widely used drugs—hydrochlorothiazide, voriconazole, and tacrolimus—as Group 1 carcinogens. Despite this, experts stress that patients should not stop treatment as the benefits for hypertension, fungal infections, and organ transplant rejection far outweigh the cancer risk. The drugs are on the WHO Model List of Essential Medicines and are commonly prescribed in India.