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VERVE-102 Gene Therapy Lowers LDL by 62% After Single Infusion: New Hope for Cholesterol

Target:UPSC GS-IIIMPSCSSC GATeachingPrelims HighMains MediumStatic GK Link
18 Aug 2026
~2 min
Source: Indian Express
Key Data:62% LDL reduction88% PCSK9 reduction78 mg/dL average decrease18 months follow-up20-22% risk reduction per 1 mmol/L
Bodies:Eli LillyVerve Therapeutics
Practice MCQs from today's news ▸
What This Article Covers

1.VERVE-102 is a one-time, permanent gene editing treatment targeting the PCSK9 gene to lower LDL cholesterol.

2.Phase 1 trial showed 62% reduction in LDL and 88% reduction in PCSK9 levels, with effects lasting at least 18 months.

3.Currently considered only for high-risk patients; long-term safety and efficacy remain unproven.

The Big Picture
Prelims · HighMains · Medium

VERVE-102 is a novel in vivo gene editing therapy that permanently switches off the PCSK9 gene in liver cells, leading to a 62% reduction in LDL cholesterol for up to 18 months after a single intravenous infusion. While promising, it is still in phase 1 trials and not yet a replacement for statins or other medications.

Exam Lens

Quick Exam Facts From News

LDL Reduction62% after single infusion
PCSK9 Reduction88% (highest-dose group)
Avg LDL Decrease78 mg/dL after 4 weeks
Risk Reduction (per 1 mmol/L)20-22%
Longest Follow-up18 months

1-Minute Revision

  • ›LDL Reduction: 62% after single infusion
  • ›PCSK9 Reduction: 88% (highest-dose group)
  • ›Target this Data: 62% reduction in LDL cholesterol, 88% reduction in PCSK9, 78 mg/dL average decrease in highest-dose group.
  • ›Target this Nodal Body: Eli Lilly and Verve Therapeutics (US pharma companies developing VERVE-102).
  • ›Target this Legal Point: No direct legal provision; focus on ethical implications of permanent human gene editing.

Mastered this topic? Test your knowledge with a full MCQ quiz.

Practice exam-style questions, track your score, and strengthen your recall.

Q1Static LinkageEasy

Which gene is targeted by the experimental therapy VERVE-102 to lower LDL cholesterol?

Q2Statement-basedHard

Consider the following statements regarding the VERVE-102 trial:

1. VERVE-102 uses in vivo gene editing to permanently switch off the PCSK9 gene in liver cells.

2. The trial followed participants for a maximum of 12 months.

3. The therapy is currently recommended as a replacement for statins.

Which of the statements given above is/are correct?

Q3Data-centricMedium

According to the VERVE-102 phase 1 trial, what was the average reduction in LDL cholesterol (in mg/dL) in the highest-dose group after four weeks?

Q4Application/ImpactMedium

What is the primary advantage of VERVE-102 over traditional cholesterol-lowering treatments such as statins?

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